GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs911119 | 1 | rs6036476 | chr20:23610308 | CST9 | chr20:23583049-23586610:- | -0.51 | -4.73 | 7.71E-6 | Chronic kidney disease |
| THYM | cis | rs911119 | 1 | rs6036478 | chr20:23611359 | CST9 | chr20:23583049-23586610:- | -0.51 | -4.73 | 7.71E-6 | Chronic kidney disease |
| THYM | cis | rs2120019 | 1 | rs60425110 | chr15:75333000 | PPCDC | chr15:75315927-75343066:+ | 0.27 | 4.85 | 4.8E-6 | Blood trace element (Zn levels) |
| THYM | cis | rs60843830 | 1 | rs60484953 | chr2:221560 | SH3YL1 | chr2:218138-264810:- | -0.31 | -4.44 | 2.41E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs911119 | 1 | rs6048956 | chr20:23609301 | CST9 | chr20:23583049-23586610:- | -0.51 | -4.73 | 7.71E-6 | Chronic kidney disease |
| THYM | cis | rs9876781 | 1 | rs60512868 | chr3:48483445 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -4.33 | 3.75E-5 | Longevity |
| THYM | cis | rs454422 | 1 | rs6053816 | chr20:5970750 | MCM8 | chr20:5931298-5975829:+ | -0.2 | -4.21 | 5.84E-5 | HIV-1 viral setpoint |
| THYM | cis | rs2243480 | 1 | rs60683927 | chr7:65394768 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 4.9 | 3.88E-6 | Diabetic kidney disease |
| THYM | cis | rs2143950 | 1 | rs60693825 | chr14:35514456 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.18 | 6.43E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs60693825 | chr14:35514456 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 5.03 | 2.32E-6 | Atopic dermatitis |
| THYM | cis | rs17396122 | 1 | rs60710459 | chr2:48687857 | FOXN2 | chr2:48541795-48606434:+ | 0.27 | 4.21 | 5.77E-5 | Schizophrenia |
| THYM | cis | rs7679 | 1 | rs6073966 | chr20:44570192 | TP53RK | chr20:45313005-45318276:- | -0.44 | -4.47 | 2.13E-5 | HDL cholesterol;Triglycerides;Gut microbiota (functional units) |
| THYM | cis | rs60843830 | 1 | rs60843830 | chr2:286756 | SH3YL1 | chr2:218138-264810:- | -0.32 | -4.63 | 1.14E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs9309473 | 1 | rs60844734 | chr2:73623205 | ALMS1P | chr2:73872046-73912692:+ | 0.62 | 4.72 | 8.01E-6 | Metabolite levels |
| THYM | cis | rs9473555 | 1 | rs60982898 | chr6:49385806 | CENPQ | chr6:49431096-49460820:+ | -0.24 | -4.37 | 3.16E-5 | Folate pathway vitamin levels |